The notes on Genius suggest that this “confess thyself” is about admitting fault of some kind on the point of inquiry. Sure, fair play.
But – I cannot help but wonder about confession in the religious sense in a passage that is ABOUT the bible. There’s a lot of interesting exploration to be found in looking at the historical context of the Protestant/Catholic issues of the time.
It was illegal to be Catholic at this time but that doesn’t mean no one was Catholic nor that artifacts of Catholicism weren’t all over the Renaissance in England. This might be a really potent moment to look at through that lens.